University at Buffalo 3 credits Structural Biology
The field of Structural Biology investigates the structure-function relationships of biological macromolecules at the molecular level. Understanding the interplay between structure and function provides valuable insight into fundamental biological processes that underlie healthy and diseased states. This 3-credit course is designed to provide students with a detailed overview of methods used to determine biological macromolecular structures. The course will begin with a brief overview of mathematical concepts such as the Fourier Transform required for understanding the methods to be discussed. The course will then describe the primary methods used to determine biological structures including X-ray crystallography/diffraction, cryo-electron microscopy, and scattering techniques. Classes will include lectures and tutorials with modern crystallographic software programs. By the end of the course, students will know how to process and determine 3D atomic structures of biological macromolecules using real experimental datasets.
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