University of Wisconsin-Madison 1 credit PHM SCI
Biochemical and spectrophotometric basis of molecular target assays in drug development. Different types of in vitro and cellular assays - how to choose the best one for the problem at hand. On-target and off-target activity. Uses and limitations of biochemical assays, biomarkers, and animal models. Challenges of translating pre-clinical data into clinical assumptions. Biases on non-quantifiable data. Critical evaluation of case studies and experimental assays on infectious diseases, auto-immune diseases, and CNS disorders. Designing proper assays according to drug development projects hypotheses.
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