University of Arizona 2 credits Pharmacology & Toxicology
Epigenetics is the study of heritable changes in gene function that occur in the absence of changes in DNA sequence. Epigenetic mechanisms of gene control are important to orderly cell, tissue, and organismal development and the disruption of these mechanisms participates in the etiology of complex human disease. Topics include overview and concepts of epigenetics, histones and their modifications, DNA methylation, chromatin structure, RNAi, model organisms, nuclear transplantation and genome reprogramming, epigenetic and epigenomic technologies, and therapeutic agents that target epigenetic mechanisms.
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