Pennsylvania State University 1 credit BMS
Genomic instability is a major hallmark of carcinogenesis. This course will examine how various forms of genome instability promote cellular transformation. The impact of both inherited and somatic mutations will be evaluated. Mechanisms of genomic instability will be explored, to understand how their dysregulation results in cancer. Epigenetic mechanisms of carcinogenesis will also be covered. Finally, novel therapeutic approaches that exploit tumor-specific mutations will be presented. As the part of this course, students will evaluate seminal research papers and the most recent findings in the literature, and learn the relevant experimental approaches employed in the field.
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