Pathways from Bed to Bedside

Course Description

The course will emphasize diverse pathways from laboratory discoveries to product commercialization in Tissue Engineering and Regenerative Medicine (TERM). Depending on the field of discovery, pathways can be quite dissimilar, e.g. devices, biologics, drugs, or combination products. The foundational sciences include: biomaterials, biological processes including cell biology and physiology, genomics, proteomics, metabolomics, stem cell differentiation, growth factors, and tissue/organ development. An overarching core principle is engineering design. The course will be divided into 3 modules: Discovery and validation, Transition from laboratory prototype to fixed prototype, Progression through clinical trials. Although scale-up manufacturing and commercialization will be discussed, these final steps to the market-place will not be covered in detail. Students will work in teams. Each team will select a TERM project with a specific type of bench to bedside pathway (team size will depend on the class size). However, other BME areas may be included, e.g. microelectron-mechanical systems (MEMS), can be designed to stimulate muscle, thus avoid atrophy while awaiting a TERM construct. For such projects, the team should choose an appropriate BME faculty advisor to guide them. Reading material and writing/speaking assignments will be the basis for in-class discussions with embellishment of specific engineering or scientific principles. 3 credits

Code

BME 525

Credits

3

Subject

BME