Temple University 1.5 credit BIOL
This course provides a focused examination and analysis of the basic structures and properties of RNA and DNA; the enzymes that synthesize or modify these biomolecules; and biotechnological applications. The synthesis and purification of DNA and RNA will be reviewed along with detection methodologies, including enzymatic amplification, array analysis, and amplification-free (direct) approaches. Nucleic acid sequencing technologies, including the analysis of ancient or degraded DNA and emerging nanopore-based sequencing approaches, will be surveyed. Finally, the course will examine how the inherent ability of DNA and RNA to self-assemble can be harnessed to provide novel nanostructures with complex architectures, and that show promise in biomedical and biotechnological applications. Note: Biochemistry Majors who have completed CHEM 4375 or CHEM 4404 or BIOL 5501 with a minimum grade of C may register for BIOL 5521 with permission from instructor.
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