Temple University 3 credits BIOL
The term "epigenetics" describes a heritable effect on chromosome or gene function that is not accompanied by a change in DNA sequence. Recent findings suggest an important role of epigenetics in both normal development and cancer. This course provides an overview of the field and examines selected phenomena in several eukaryotes, mechanisms regulating these effects, and their phenotypic consequences when normal regulation is lost. Topics include gene regulation through chromatin modification (acetylation, methylation), genomic imprinting, mechanisms of silencing (including small interfering RNAs), and the role of epigenetics in human diseases and cancer.
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